Raith Rovers and Dunfermline will not be playing each other this Friday due to the Pars having a coronavirus case.
It was scheduled to be the third time both Fife teams were going to meet in the Championship this season.
A number of Pars players are self-isolating.
It means they have an insufficient number of players to take part in the game.
An investigation is going to take place to look at the circumstances leading to the postponement.
A statement from the SPFL read: "Dunfermline have informed the SPFL that they have had a confirmed case of COVID-19.
"The club has been liaising with the Scottish FA, the Elite Sport Clinical Advisory Group and Test and Protect to establish whether any other players or staff will need to self-isolate.
"Dunfermline have now informed the SPFL that, following conclusion of that process and due to the number of players now self-isolating, they have insufficient players to fulfil the fixture.
"As a result, and in line with standard procedure, the SPFL has postponed the fixture pending an investigation into the circumstances leading to the postponement.
"The SPFL will continue to liaise with Dunfermline Athletic in the coming days. "